Why Hydroxychloroquine Works

BY Herschel Smith
1 month, 2 weeks ago

This article, written at Medium but taken down and thus only on archive, comes to us via reader JJ.

Your red blood cells carry oxygen from your lungs to all your organs and the rest of your body. Red blood cells can do this thanks to hemoglobin, which is a protein consisting of four “hemes”. Hemes have a special kind of iron ion, which is normally quite toxic in its free form, locked away in its center with a porphyrin acting as it’s ‘container’. In this way, the iron ion can be ‘caged’ and carried around safely by the hemoglobin, but used to bind to oxygen when it gets to your lungs.

When the red blood cell gets to the alveoli, or the little sacs in your lungs where all the gas exchange happens, that special little iron ion can flip between FE2+ and FE3+ states with electron exchange and bond to some oxygen, then it goes off on its little merry way to deliver o2 elsewhere.

Here’s where COVID-19 comes in. Its glycoproteins bond to the heme, and in doing so that special and toxic oxidative iron ion is “disassociated” (released). It’s basically let out of the cage and now freely roaming around on its own. This is bad for two reasons:

Editorial comment: This is not exactly like, but similar to carboxyhemoglobin, where carbon dioxide binds to your hemoglobin, staying there unless you’re put inside a hyperbaric chamber, and thus preventing oxygen, O2, from binding to your hemoglobin.

1) Without the iron ion, hemoglobin can no longer bind to oxygen. Once all the hemoglobin is impaired, the red blood cell is essentially turned into a Freightliner truck cab with no trailer and no ability to store its cargo.. it is useless and just running around with COVID-19 virus attached to its porphyrin. All these useless trucks running around not delivering oxygen is what starts to lead to desaturation, or watching the patient’s spo2 levels drop. It is INCORRECT to assume traditional ARDS and in doing so, you’re treating the WRONG DISEASE. Think of it a lot like carbon monoxide poisoning, in which CO is bound to the hemoglobin, making it unable to carry oxygen. In those cases, ventilators aren’t treating the root cause; the patient’s lungs aren’t ‘tiring out’, they’re pumping just fine. The red blood cells just can’t carry o2, end of story. Only in this case, unlike CO poisoning in which eventually the CO can break off, the affected hemoglobin is permanently stripped of its ability to carry o2 because it has lost its iron ion. The body compensates for this lack of o2 carrying capacity and deliveries by having your kidneys release hormones like erythropoietin, which tell your bone marrow factories to ramp up production on new red blood cells with freshly made and fully functioning hemoglobin. This is the reason you find elevated hemoglobin and decreased blood oxygen saturation as one of the 3 primary indicators of whether the shit is about to hit the fan for a particular patient or not.

2) That little iron ion, along with millions of its friends released from other hemes, are now floating through your blood freely. As I mentioned before, this type of iron ion is highly reactive and causes oxidative damage. It turns out that this happens to a limited extent naturally in our bodies and we have cleanup & defense mechanisms to keep the balance. The lungs, in particular, have 3 primary defenses to maintain “iron homeostasis”, 2 of which are in the alveoli, those little sacs in your lungs we talked about earlier. The first of the two are little macrophages that roam around and scavenge up any free radicals like this oxidative iron. The second is a lining on the walls (called the epithelial surface) which has a thin layer of fluid packed with high levels of antioxidant molecules.. things like abscorbic acid (AKA Vitamin C) among others. Well, this is usually good enough for naturally occurring rogue iron ions but with COVID-19 running rampant your body is now basically like a progressive state letting out all the prisoners out of the prisons… it’s just too much iron and it begins to overwhelm your lungs’ countermeasures, and thus begins the process of pulmonary oxidative stress. This leads to damage and inflammation, which leads to all that nasty stuff and damage you see in CT scans of COVID-19 patient lungs. Ever noticed how it’s always bilateral? (both lungs at the same time) Pneumonia rarely ever does that, but COVID-19 does… EVERY. SINGLE. TIME.

Once your body is now running out of control, with all your oxygen trucks running around without any freight, and tons of this toxic form of iron floating around in your bloodstream, other defenses kick in. While your lungs are busy with all this oxidative stress they can’t handle, and your organs are being starved of o2 without their constant stream of deliveries from red blood cell’s hemoglobin, and your liver is attempting to do its best to remove the iron and store it in its ‘iron vault’. Only its getting overwhelmed too. It’s starved for oxygen and fighting a losing battle from all your hemoglobin letting its iron free, and starts crying out “help, I’m taking damage!” by releasing an enzyme called alanine aminotransferase (ALT). BOOM, there is your second of 3 primary indicators of whether the shit is about to hit the fan for a particular patient or not.

Eventually, if the patient’s immune system doesn’t fight off the virus in time before their blood oxygen saturation drops too low, ventilator or no ventilator, organs start shutting down. No fuel, no work. The only way to even try to keep them going is max oxygen, even a hyperbaric chamber if one is available on 100% oxygen at multiple atmospheres of pressure, just to give what’s left of their functioning hemoglobin a chance to carry enough o2 to the organs and keep them alive. Yeah we don’t have nearly enough of those chambers, so some fresh red blood cells with normal hemoglobin in the form of a transfusion will have to do.

The core point being, treating patients with the iron ions stripped from their hemoglobin (rendering it abnormally nonfunctional) with ventilator intubation is futile, unless you’re just hoping the patient’s immune system will work its magic in time. The root of the illness needs to be addressed.

Best case scenario? Treatment regimen early, before symptoms progress too far. Hydroxychloroquine (more on that in a minute, I promise) with Azithromicin has shown fantastic, albeit critics keep mentioning ‘anecdotal’ to describe the mountain, promise and I’ll explain why it does so well next. But forget straight-up plasma with antibodies, that might work early but if the patient is too far gone they’ll need more. They’ll need all the blood: antibodies and red blood cells. No help in sending over a detachment of ammunition to a soldier already unconscious and bleeding out on the battlefield, you need to send that ammo along with some hemoglobin-stimulant-magic so that he can wake up and fire those shots at the enemy.

All that hilariously misguided and counterproductive criticism the media piled on chloroquine (purely for political reasons) as a viable treatment will now go down as the biggest Fake News blunder to rule them all. The media actively engaged their activism to fight ‘bad orange man’ at the cost of thousands of lives. Shame on them.

How does chloroquine work? Same way as it does for malaria. You see, malaria is this little parasite that enters the red blood cells and starts eating hemoglobin as its food source. The reason chloroquine works for malaria is the same reason it works for COVID-19 — while not fully understood, it is suspected to bind to DNA and interfere with the ability to work magic on hemoglobin. The same mechanism that stops malaria from getting its hands on hemoglobin and gobbling it up seems to do the same to COVID-19 (essentially little snippets of DNA in an envelope) from binding to it. On top of that, Hydroxychloroquine (an advanced descendant of regular old chloroquine) lowers the pH which can interfere with the replication of the virus. Again, while the full details are not known, the entire premise of this potentially ‘game changing’ treatment is to prevent hemoglobin from being interfered with, whether due to malaria or COVID-19.

But don’t tell Dr. Zack Moore that he traffics in fake news with his counsel to North Carolina hospitals that they shouldn’t use hydroxychloroquine (yes, I have such a document).  I guess he cares too much about politics to be concerned about saving lives.


Comments

  1. On April 8, 2020 at 11:31 pm, Georgiaboy61 said:

    @ Herschel Smith

    Excellent detective work, sir – thank you for posting it.

  2. On April 9, 2020 at 12:14 am, 41mag said:

    Man this makes sense, thanks Herschel! I can sleep a little more now lol.

  3. On April 9, 2020 at 7:29 am, Fred said:

    If you or family catch this bug make sure to ask for Zinc supplement on top of both Hydroxychloroquine and the zpack. It won’t hurt you and it may help.

    This has got to stop. He calls the propagandists willful attack against the use of this drug a “blunder.” It’s not a blunder. Quit excusing communists for being murderers. Everything that the mass news does is carefully crafted propaganda.

  4. On April 9, 2020 at 6:14 pm, Billll said:

    The lack of oxygen seems to weaken the cells in the lungs and makes life easier for ordinary bacteria, The Z-Pac counteracts this while the HCQ does its thing. I haven’t heard why the Zinc helps, but all the evidence suggests it does.

  5. On April 11, 2020 at 8:35 am, Todd said:

    Did you find any reason why this was taken down? Other than medium being a liberal mouthpiece of course.

  6. On April 11, 2020 at 12:34 pm, Paul B said:

    It depends on what the elites have in mind for us. If they are wanting to cull the herd they would not allow any treatment to be surfaced.

    It flat out amazes me how little our leaders know about how things work.

  7. On April 13, 2020 at 9:27 am, Cancemi Mark said:

    HCQ is an “ionophore” which facilitates the entry of Zn into the cells. Zn inhibits the replication of the viral RNA, thus halting the reproduction of the virus in your body.

    Supplemental Zn is a benefit, albeit limited because it’s ability to enter a cell is limited by charges and concentration gradients and transport through regulated channels in the cell wall. HCQ opens up these channels to Zn. Even if you don’t supplement Zn, your body has it already and labeling studies have shown the increase in intracellular Zn simply by taking HCQ alone. It’s even more impressive if Zn is Supplementes

    The initiation of HCQ/Zn/Azythro EARLY in the course of infection is the key. While most people can handle the virus in and of itself, those who develop high viral loads and get the “cytokine storm” are at the greatest danger of severe complications and death.

    This also argues further for instituting PROPHYLACTIC HCQ/Zn in high risk people. Health care workers, particularly those in the ER and anesthesiologists who intubate patients all day and risk exposure from aerosolised virus, should be offered the option of taking this regimen. At the doses required for prophylaxis, the side effects are basically ZERO. The benefit is immeasurable.

    YES, there is a huge coverup with an underlying agenda in all of this. Fauci is complicit, and has been wrong on CoVid19 as well as H1N1, and SARS. I expect Trump will tell him “You’re Fired!” this week because Fauci is now presenting a false narrative that Trump didn’t listen to the advice provided by Fauci and other so called “experts” like the WHO. They’ve been proven wrong again and again, and are trying to put it all on Trump. They’re lying and the MSM is also complicit

    Trump won’t take that crap.

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This article is filed under the category(s) Politics and was published April 8th, 2020 by Herschel Smith.

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